Generic pill for trihexyphenidyl

National Library of Medicine and Drugs

While the external hemorrhoids are innervated by the same nerves that supply the skin in the perianal region, the internal hemorrhoids aren't innervated at all and do not cause pain, even when enlarged. Let us be grateful to Mother Nature for small mercies! What is trihexyphenidyl Artane? These symptoms are seen in a significant number of hospitalized mental patients. They may be characterized by motor restlessness, be of the dystonic type, or they may resemble parkinsonism. Since antidyskinetics tend to decrease the secretions of the body, it is possible that the flow of breast milk may be reduced in some patients. aved.info benicar

Trihexyphenidyl drug interactions

Since trihexyphenidyl has atropine-like properties, patients on long-term treatment should be carefully monitored for untoward reactions. Phenelzine sulfate should be used with caution in combination with antihypertensive drugs, including thiazide diuretics and β-blockers, since exaggerated hypotensive effects may result. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Very disappointed in it and disappointed. Store in a tightly closed container at room temperature between 59-86 degrees F 15-30 degrees C away from light and moisture. not store in the bathroom. Do not freeze. Keep all medicines away from children and pets.

Side effects of trihexyphenidyl

Safety for the use of trifluoperazine hydrochloride during pregnancy has not been established. Therefore, it is not recommended that the drug be given to pregnant patients except when, in the judgment of the physician, it is essential. The potential benefits should clearly outweigh possible hazards. There are reported instances of prolonged jaundice, extrapyramidal signs, hyperreflexia or hyporeflexia in newborn infants whose mothers received phenothiazines. Take this medication at least 1 hour before antacids containing magnesium, aluminum, or calcium. Allow at least 1-2 hours between doses of trihexyphenidyl and certain drugs for diarrhea adsorbent antidiarrheals such as kaolin, pectin, attapulgite. Take this medication at least 2 hours after ketoconazole. Antacids and some drugs for diarrhea may prevent the full absorption of trihexyphenidyl, and this product may prevent the complete absorption of ketoconazole when these products are taken together.

Trihexyphenidyl adult dosage

Patients with cardiac, liver, or kidney disorders, or with hypertension, should be closely monitored. Taking synthetic or fiber-based bulking laxatives. This is why indigestible fiber in foods and laxatives is universally referred to by doctors as a "bulking agent. Phenelzine sulfate should also not be used in combination with buspirone HCl, since several cases of elevated blood pressure have been reported in patients taking MAO inhibitors who were then given buspirone HCl. At least 14 days should elapse between the discontinuation of Phenelzine sulfate and the institution of another antidepressant or buspirone HCl, or the discontinuation of another MAO inhibitor and the institution of Phenelzine sulfate.



Does trihexyphenidyl interact with other medications

In the case of external hemorrhoidal disease, the pain emanates primarily from the inflammation of the skin protruded by dilated hemorrhoidal veins, by the venal thrombosis, or both. The external dilation that can be seen or felt is caused by venal thrombosis. The thrombosis is caused by a blood clot thrombus. Initiate with low dosage; titrate dosage gradually. NOTE: Intracranial bleeding has been reported in association with the increase in blood pressure. Trifluoperazine Hydrochloride Tablets, USP and have their WBC followed until recovery. Also, any spoiled or improperly refrigerated, handled, or stored protein-rich foods such as meats, fish, and dairy products, including foods that may have undergone protein changes by aging, pickling, fermentation, or smoking to improve flavor should be avoided. EKG changes-particularly nonspecific, usually reversible Q and T wave distortions-have been observed in some patients receiving phenothiazine antipsychotics. At any moment, you can make a conscious decision to tense the external anal sphincter b and terminate the bowel movement or retain flatus. The ability to keep feces and flatus inside until you consciously decide to move bowels or release gases is an essential social skill acquired by around the 3rd birthday. Each 5 mL teaspoonful for oral administration contains 2 mg trihexyphenidyl hydrochloride and alcohol 5% in a clear, colorless, lime-mint flavored preparation. In addition, it contains the following inactive ingredients: citric acid, flavoring, methylparaben, propylparaben, purified water and sorbitol solution. In children, excitement may occur first, and may be followed by loss of coordination, drowsiness, loss of consciousness, seizures. There are no data on the lethal dose in man. The pathophysiologic effects of massive overdosage may persist for several days, since the drug acts by inhibiting physiologic enzyme systems. With symptomatic and supportive measures, recovery from mild overdosage may be expected within 3 to 4 days. If your doctor has prescribed this medication, take it as directed. Death has been reported following overdosage. Therefore, immediate hospitalization, with continuous patient observation and monitoring throughout this period, is essential. Therefore, not use this product to treat in children younger than 6 years unless specifically directed by the doctor. Prescribers or other health professionals should inform patients, their families, and their caregivers about the benefits and risks associated with treatment with Phenelzine sulfate and should counsel them in its appropriate use. A patient Medication Guide about "Antidepressant Medicines, Depression and other Serious Mental Illness, and Suicidal Thoughts or Actions" is available for Phenelzine sulfate. The prescriber or health professional should instruct patients, their families, and their caregivers to read the Medication Guide and should assist them in understanding its contents. Patients should be given the opportunity to discuss the contents of the Medication Guide and to obtain answers to any questions they may have. The complete text of the Medication Guide is reprinted at the end of this document. Monoamine oxidase inhibitors and possessing significant activity may intensify the anticholinergic effects of antidyskinetic agents because of the secondary anticholinergic activities of these medications. Because of increased sedative effects, patients should be cautioned to avoid the use of alcohol or other CNS depressants while taking trihexyphenidyl.



Important information

Dizziness, lightheadedness, or fainting may occur, especially when you get up from lying or sitting. Getting up slowly may help. If the problem continues or gets worse, check with your doctor. Was put on a very low dose. Started out at half a pill 2times a day for a week. Then bumped up to a full pill 2 times a day. I started having headaches at first, then my eyes would start to bun and go blurry. When my tremors started getting worse I looked up side effects and noticed it is a side effect. I shake bad enough without the pill. The rest went down the drain. I will not go back on it. I'd rather just deal with the tremors then to deal with real bad shaking. The size and frequency of dose of Trihexyphenidyl HCl needed to control extrapyramidal reactions to commonly employed tranquilizers, notably the phenothiazines, thioxanthenes, and butyrophenones, must be determined empirically. The total daily dosage usually ranges between 5 and 15 mg, although, in some cases, these reactions have been satisfactorily controlled on as little as 1 mg daily. It may be advisable to commence therapy with a single 1 mg dose. If the extrapyramidal manifestations are not controlled in a few hours, the subsequent doses may be progressively increased until satisfactory control is achieved. Satisfactory control may sometimes be more rapidly achieved by temporarily reducing the dosage of the tranquilizer on instituting Trihexyphenidyl HCl therapy and then adjusting dosage of both drugs until the desired ataractic effect is retained without onset of extrapyramidal reactions. Known hypersensitivity to trihexylphenidyl or any ingredient in the formulation. Never stop an antidepressant medicine without first talking to a healthcare provider. Stopping an antidepressant medicine suddenly can cause other symptoms. Antidepressants increased the risk compared to placebo of suicidal thinking and behavior suicidality in children, adolescents, and young adults in short-term studies of major depressive disorder MDD and other psychiatric disorders. Anyone considering the use of Phenelzine sulfate or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Phenelzine sulfate is not approved for use in pediatric patients. Since ARTANE trihexyphenidyl has atropine-like properties, patients on long-term treatment should be carefully monitored for untoward reactions. Children: Use and dose must be determined by your doctor. Take this by with or without food as directed by your doctor, usually twice a day. The most important reaction associated with Phenelzine sulfate administration is the occurrence of hypertensive crises, which have sometimes been fatal. If the decision is made to administer Phenelzine sulfate concurrently with other antidepressant drugs, or within less than 10 days after discontinuation of antidepressant therapy, the patient should be cautioned by the physician regarding the possibility of adverse drug interaction. The total daily intake of Trihexyphenidyl HCl tablets is tolerated best if divided into 3 doses and taken at mealtimes. The lid moves every few seconds for a minute or two. nexium



Highlights for trihexyphenidyl

Phenelzine sulfate is extensively metabolized, primarily by oxidation via monoamine oxidase. After oral administration of 13C 6-Phenelzine, 73% of the administered dose was recovered in urine as phenylacetic acid and parahydroxyphenylacetic acid within 96 hours. Acetylation to N 2-acetylPhenelzine is a minor pathway. The spasm of the anal sphincter complex caused by the prolapsed hemorrhoids. It is not known whether trihexyphenidyl will be harmful to an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment. Whatever you happen to have, all of these conditions are addressed in depth in the and guides. If you are affected by IBS, please also study the guide. The management of NMS should include 1 immediate discontinuation of antipsychotic drugs and other drugs not essential to concurrent therapy, 2 intensive symptomatic treatment and medical monitoring, and 3 treatment of any concomitant serious medical problems for which specific treatments are available. There is no general agreement about specific pharmacological treatment regimens for uncomplicated NMS. Competitively inhibits acetylcholine or other cholinergic stimuli at autonomic effectors innervated by postganglionic nerves. You may not be able to take trihexyphenidyl or you may require a dosage adjustment or special monitoring if you are taking any of the medicines listed above. The following information includes only the average doses of benztropine, biperiden, ethopropazine, procyclidine, and trihexyphenidyl. Dosage should be individualized. The initial dose should be low and then increased gradually, especially in patients over 60 years of age. Whether Trihexyphenidyl HCl may best be given before or after meals should be determined by the way the patient reacts. Postencephalitic patients, who are usually more prone to excessive salivation, may prefer to take it after meals and may, in addition, require small amounts of atropine which, under such circumstances, is sometimes an effective adjuvant. If Trihexyphenidyl HCl tends to dry the mouth excessively, it may be better to take it before meals, unless it causes nausea. If taken after meals, the thirst sometimes induced can be allayed by mint candies, chewing gum or water. Dry mouth, blurred vision, dizziness, nausea, nervousness.



Usual Dosage: 2 mg to 4 mg daily

Many adults with CP get jobs if they have good support from their family and community. At least 14 days should elapse between discontinuation of an MAO inhibitor and initiation of treatment with bupropion hydrochloride. If other options fail, your doctor may suggest surgery. In a procedure called a myectomy, your surgeon will remove some of the muscles and nerves around your eyelid. If hemorrhoidal disease or anal fissures are left untreated, and their causes aren't eliminated, there is a distinct possibility of further anorectal complications such as fistulas, and abscesses, which in most cases require surgical intervention. Toxic blood levels of Phenelzine have not been established, and assay methods are not practical for clinical or toxicological use. generic pill for lasix



Trihexyphenidyl dosing information

Antidepressants are medicines used to treat depression and other illnesses. It is important to discuss all the risks of treating depression and also the risks of not treating it. Patients and their families or other caregivers should discuss all treatment choices with the healthcare provider, not just the use of antidepressants. Amazon in advance, and keep it on hand just in case. The "occult" in the FOBT means hidden, not mystic. Tell your doctor if your condition persists or worsens. If GI upset occurs, trihexyphenidyl may be taken with food. This is irrespective of other causes, be it natural child birth, severe diarrhea, anal intercourse, weight lifting, occupational hazards, or some others. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Ask your doctor when to start or stop taking this medication. Patients to be treated with Trihexyphenidyl HCl should have a gonioscope evaluation and close monitoring of intraocular pressures at regular periodic intervals. Sometimes these may be accompanied by involuntary movements of extremities. In rare instances, these involuntary movements of the extremities are the only manifestations of tardive dyskinesia. A variant of tardive dyskinesia, tardive dystonia, has also been described. Pramlintide slows down the movement of food through your stomach. Some other medicines such as anticholinergics or antispasmodics do the same thing. Some medicines may speed up the movement of food through your stomach. Asymptomatic enlarged hemorrhoids do not require any treatment except dietary modification exclusion of fiber and the maintenance of small, soft stools, which don't require straining. Ask your doctor or pharmacist about using this product safely. No carcinogenicity studies or adequate genotoxicity or fertility studies have been conducted for trihexyphenidyl. Limit the use of alcohol and certain other that cause drowsiness.



Use of trihexyphenidyl

Ataxia, shock-like coma, toxic delirium, manic reaction, convulsions, acute anxiety reaction, precipitation of schizophrenia, transient respiratory and cardiovascular depression following ECT. These kind of picture-perfect, finger-sized, soft and moist stools require no more effort to pass out than urination. In other words, normal defecation is a practically unnoticeable act, just like it was when you were a healthy child. Store at room temperature between 59-86 degrees F between 15-30 degrees C away from moisture and light. Store in a tightly closed container. not store in the bathroom. What are the possible side effects of trihexyphenidyl Artane? There is conflicting evidence as to whether or not MAO inhibitors affect glucose metabolism or potentiate hypoglycemic agents. This should be kept in mind if Phenelzine sulfate is administered to diabetics. Some people have spasms all day long. They might go on for days, weeks, or even months. That can upset you and affect your quality of life. Important: The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, blogs, or WebMD Answers are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. The prolapse of external hemorrhoids is caused by the dilation and thrombosis of hemorrhoidal veins. fluticasone medicare



List of trihexyphenidyl side effects

Where can I get more information? Suicide is a known risk of depression and certain other psychiatric disorders, and these disorders themselves are the strongest predictors of suicide. There has been a long-standing concern, however, that antidepressants may have a role in inducing worsening of depression and the emergence of suicidality in certain patients during the early phases of treatment. This information is generalized and not intended as specific medical advice. Ongoing treatment for CP focuses on continuing and adjusting existing treatments and adding new treatments as needed. Doses of Phenelzine sulfate in pregnant mice well exceeding the maximum recommended human dose have caused a significant decrease in the number of viable offspring per mouse. In addition, the growth of young dogs and rats has been retarded by doses exceeding the maximum human dose. Your doctor will adjust your dose, depending on your condition; however, the dose is usually not more than 16 mg a day. Internal hemorrhoids do not cause pain, unless they prolapse outside the anus. Care should be taken to administer this drug slowly in order to avoid producing an excessive hypotensive effect. Fever should be managed by means of external cooling. If you are experiencing an acute stage of hemorrhoidal disease, follow your doctor's directions until the symptoms subside. Do not drop prescribed medication or recommended laxatives, unless you successfully replace them by the safer means, methods, and approaches recommended on this site. If agents such as sedatives, narcotics, anesthetics, tranquilizers or alcohol are used either simultaneously or successively with the drug, the possibility of an undesirable additive depressant effect should be considered. She might refer you to a neurologist or other specialist. How Is It Treated? Prophylactic administration of anticholinergic agents, such as trihexyphenidyl, as a prevention of drug-induced parkinsonism during neuroleptic therapy is not recommended. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. ARTANE trihexyphenidyl is contraindicated in patients with hypersensitivity to trihexyphenidyl HCl or to any of the tablet or elixir ingredients. Antipsychotic drugs elevate prolactin levels; the elevation persists during chronic administration. Chewable forms of this medication should be chewed thoroughly before swallowing.



What other drugs will affect trihexyphenidyl

The spasm of the anal sphincter may cause the thrombosis of underlining hemorrhoidal veins, which in turn may cause new external hemorrhoids, or aggravate existing ones. Patients to be treated with trihexyphenidyl should have a gonioscope evaluation prior to initiation of therapy and close monitoring of intraocular pressures. The use of anticholinergic drugs may precipitate angle closure with an increase in intraocular pressure. If blurring of vision occurs during therapy, the possibility of narrow angle glaucoma should be considered. Blindness has been reported due to aggravation of narrow angle glaucoma. Certain food beets, blueberries, black licorice, black coffee, dark chocolate supplements dietary iron antacids Pepto-Bismol or a sudden release of may also give stools a tar-like appearance. If you are prescribed this on a regular schedule and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. MAO inhibitors, including Phenelzine sulfate, are contraindicated in patients receiving guanethidine. Occasionally it is necessary to lower the dosage of trifluoperazine hydrochloride or to discontinue the drug. symbicort



Consult your doctor before -feeding

When trihexyphenidyl is used concomitantly with levodopa, the usual dose of each may need to be reduced. Careful adjustment is necessary, depending on side effects and degree of symptom control. A trihexyphenidyl dosage of 3 to 6 mg daily, in divided doses, is usually adequate. If you are using a sustained-release product, an empty tablet shell may appear in your stool. This is harmless. The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using tolterodine, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain problems , slow heartbeat, QT prolongation in the family history of certain heart problems QT prolongation in the EKG, sudden cardiac death. There was considerable variation in risk of suicidality among drugs, but a tendency toward an increase in the younger patients for almost all drugs studied. There were differences in absolute risk of suicidality across the different indications, with the highest incidence in MDD. The risk differences drug vs placebo however, were relatively stable within age strata and across indications. Check the labels on all your medicines such as or -and-cold products because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely. Since this medication may increase the susceptibility to heat stroke gastrointestinal GI problems, fever, heat intolerance use with caution during hot weather. Antiparkinsonism agents do not alleviate the symptoms of tardive dyskinesia, and in some instances may aggravate them. However, and tardive dyskinesia often coexist in patients receiving chronic neuroleptic treatment, and anticholinergic therapy with ARTANE trihexyphenidyl may relieve some of these parkinsonism symptoms. ARTANE trihexyphenidyl is not recommended for use in patients with tardive dyskinesia unless they have concomitant Parkinson's disease. Antiparkinsonian agents do not alleviate symptoms of tardive dyskinesia and may aggravate these symptoms. Observational studies suggest that, similar to atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality. The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristics of the patients is not clear. To date, fatal progressive necrotizing hepatocellular damage has been reported in very few patients. Reversible jaundice. There is no known effective treatment for tardive dyskinesia; antiparkinsonism agents do not alleviate the symptoms of this syndrome. If clinically feasible, it is suggested that all antipsychotic agents be discontinued if these symptoms appear. Should it be necessary to reinstitute treatment, or increase the dosage of the agent, or switch to a different antipsychotic agent, the syndrome may be masked. The nerves of the anus and rectum are highly sensitive, and particularly so in children. Dietary fiber is an indirect cause of hemorrhoidal disease and anal fissures, because it causes large stools. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.



Before taking trihexyphenidyl

Take this medication by mouth, usually 3 to 4 times a day with meals and at bedtime, or as directed by your doctor. Your doctor may start you at a low dose and increase your dose slowly to find the best dose for you. The dosage is based on your medical condition and response to therapy. Since ARTANE trihexyphenidyl has parasympatholytic activity, it should be used with caution in patients with glaucoma, obstructive disease of the gastrointestinal or genitourinary tracts, and in elderly males with possible prostatic hypertrophy. Certain kinds of surgery, which may sometimes be used for a child with severe problems. The dosage is based on your age, medical condition, and response to therapy. Despite these considerable risks and lethal outcomes, straining isn't only considered normal, but is also encouraged by doctors who advise patients to strengthen their abdominal and pelvic muscles, so they can strain even harder. Patients with arteriosclerosis or with a history of idiosyncrasy to other drugs may exhibit reactions of mental confusion, agitation, disturbed behavior, or nausea and vomiting. Such patients should be allowed to develop a tolerance through the initial administration of a small dose and gradual increase in dose until an effective level is reached. If a severe reaction should occur, administration of the drug should be discontinued for a few days and then resumed at a lower dosage. Psychiatric disturbances can result from indiscriminate use leading to overdosage to sustain continued euphoria. Instead of panicking, don't flush the toilet and run to the nearest drugstore to purchase a Fecal Occult Blood Test FOBT kit. Consult your pharmacist for further advice. To prevent a possible necrosis of strangulated hemorrhoidal tissue, an affected individual must seek immediate medical attention. When it isn't available, the prolapsed hemorrhoids should be returned back into the anal canal in order to relieve pain and prevent possible necrosis and infection. The affected area must be cleansed with warm water, which also helps to relax the anal sphincter. Petroleum jelly or non-medicated hemorrhoidal cream should be used to lubricate prolapsed hemorrhoids and the surrounding area before maneuvering them back inside the anal canal. Do not take this medicine within 1 hour of taking medicine for diarrhea. Taking these medicines too close together will make this medicine less effective. The commonly accepted recommendation to use dietary fiber for the treatment and prevention of hemorrhoidal disease or anal fissures is grossly incorrect. Dietary fiber will aggravate enlarged hemorrhoids and prevent the healing of anal fissures, because increased stool size causes additional pressure inside the anal canal. As with other anticholinergics, trihexyphenidyl may cause suppression of lactation. Therefore, trihexyphenidyl should only be used if the expected benefit to the mother outweighs the potential risk to the infant. Potential side effects associated with the use of any atropine-like drugs include constipation, drowsiness, urinary hesitancy or retention, tachycardia, dilation of the pupil, increased intraocular tension, weakness, vomiting, and headache. The usual starting dose of Phenelzine sulfate is one tablet 15 mg three times a day. Surgical treatments are reserved for the more complex cases usually 4th degree. Recurring external hemorrhoids are treated by surgical excision of the overlying skin folds and underlying veins. The procedure is performed under local anesthetic, and usually on an outpatient basis. money order generic adalat uk



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Indications and usage of trihexyphenidyl


Store away from heat and direct light

The elimination of dietary fiber to reduce stool size and density from the diet is a principal strategy for the treatment and prevention of hemorrhoidal disease and related complications. Neuroleptic Malignant Syndrome NMS has been reported in association with dose reduction or discontinuation of trihexyphenidyl. Neuroleptic Malignant Syndrome NMS has been reported in association with antipsychotic drugs. Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability irregular pulse or blood pressure, tachycardia, diaphoresis, and cardiac dysrhythmias.

Trihexyphenidyl forms and strengths

To make this point loud and clear, let me remind you again that the most debilitating hemorrhoids-related conditions, such as torture-like pain and the inability to sit or walk, aren't related to internal hemorrhoids, but external. Antidyskinetics may also be used for other conditions as determined by your doctor. Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Reviews for trihexyphenidyl

Your doctor may want you to have your eyes examined by an ophthalmologist eye doctor before and also sometime later during treatment. All patients being treated with antidepressants for any indication should be monitored appropriately and observed closely for clinical worsening, suicidality, and unusual changes in behavior, especially during the initial few months of a course of drug therapy, or at times of dose changes, either increases or decreases. Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs and dietary or herbal supplements, as well as concomitant illnesses.

Tmax of 43 minutes postdose

The total daily intake of trihexyphenidyl is tolerated best if divided into 3 doses and taken at mealtimes. The dosage is based on your age, medical condition and response to therapy. Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. In serious cases, the spasms can become so intense that your eyelids stay shut for up to several hours. Keep this important point in mind: if blood emanates from upper intestinal tract organs esophagus, stomach, duodenum, small intestine the bleeding may have started at least 24 hours before you see the first signs of it. That's how long it normally takes for chyme to turn into stool and reach the toilet bowl. For people who are severely constipated it may take even longer. This means that by the time the blood in stools is detected, the loss of blood may be considerable.

The size and frequency of dose of trihexyphenidyl hydrochloride needed to control extrapyramidal reactions to commonly employed tranquilizers, notably the phenothiazines, thioxanthenes, and butyrophenones, must be determined empirically. The total daily dosage usually ranges between 5 and 15 mg although, in some cases, these reactions have been satisfactorily controlled on as little as 1 mg daily. It may be advisable to commence therapy with a single 1 mg dose. If the extrapyramidal manifestations are not controlled in a few hours, the subsequent doses may be progressively increased until satisfactory control is achieved. Satisfactory control may sometimes be more rapidly achieved by temporarily reducing the dosage of the tranquilizer on instituting trihexyphenidyl therapy and then adjusting dosage of both drugs until the desired ataractic effect is retained without onset of extrapyramidal reactions.

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